Understanding Original Antigenic Sin (OAS) and Vaccine Effectiveness

It’s Not Biblical – Or is it???

Understanding Original Antigenic Sin (OAS) is the mechanism in which our body first encounters a pathogen, like a virus, and follows with an immunological response that involves B-cell memory to fight the infection.   That Immune response is remembered by the body and “your body will not learn to make antibodies or T-cells against new variants, and will instead continue to depend on the old response.”

This means, when you got the Covid Shot, your body built a specific immune response using B-cell Memory specific to the original variant and that memory inhibits the body’s ability to make a new response to a new variant.

If your body made a Natural Immune response without a Shot, it is able to adjust to the new variant and make the proper antigens. Mother Nature knows how to do it right, our GMO scientists don’t. For some reason the GMO derived immune response does not work the same as our bodies Natural Response to a known pathogen.

The science in a recent study concluded that the protection that natural immunity confers against severe illness remains superior to that bestowed by COVID-19 vaccines. People who survived a COVID-19 infection and weren’t vaccinated had a very high level of protection against severe or fatal COVID-19.

“The effectiveness of primary infection against severe, critical or fatal COVID-19 reinfection was 97.3%, irrespective of the variant of primary infection or reinfection” and with no evidence of waning, according to Laith Jamal Abu-Raddad, the study’s lead author and a professor of population health science, Laith Abu-Raddad of Weill Cornell Medical College, New York.

That is,  “a person who has been naturally infected at any time during the pandemic is almost completely protected from severe disease and death against any future reinfection by any variant (including omicron). “


Not the same in the Vaccinated Group.  The Original Antigenic Sin kicked in because:

“OAS operates through germinal centre reactions inside the lymph node, where high-affinity memory B-cells are produced. These cells are supercharged, in a manner of speaking, and inhibit the recruitment of naïve B-cells – B-cells that haven’t been exposed to antigens – against a new offending agent. The effect is a weak antibody response.”

“If you have been exposed to the ‘original’ strain, you are unlikely to mount efficient neutralizing antibody or T-cell responses against newer, more-different variants – no matter how many times you get exposed to these variants, and no matter how many times you inject yourself with a new shot of a COVID-19 vaccine. The vaccines based on the ancestral strain may compromise your immune system’s ability to react to newer variants. See Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure | Science

“(T)he study showed that an individual’s vaccination and infection history could and did influence their future immune response to variants, including the omicron variant.”

“The New England Journal of Medicine found that boosted individuals clear the virus more slowly than non-boosted individuals. Repeated boosting makes it harder to respond to future variants due to the inertia imposed by OAS. See: Duration of Shedding of Culturable Virus in SARS-CoV-2 Omicron (BA.1) Infection | NEJM

Another study looking at another part of the immune response showed “Research efforts have focused on antibodies that neutralize the ACE2-Spike interaction but not on non-neutralizing antibodies. Antibody-dependent phagocytosis is an immune mechanism enhanced by opsonization, where typically, more bound antibodies trigger a stronger phagocyte response. “ Importantly, prior severe SARS-CoV-2 infection provoked significant levels of S1 or RBD-specific IgA in the respiratory mucosa, which was not the case for COVID-19 vaccination (Fig. 1E and Fig. S1D). The lack of notable IgA production in the respiratory mucosal appeared to contrast with the detection of moderate but significant IgA responses in the saliva following mRNA vaccination (2122). We also examined IgM in the blood and BAL, and observed that, while detectable levels of IgM were present in the circulation of both COVID-19-vaccination group and prior infection cases, only prior infection elicited significantly elevated IgM responses in the BAL (Fig. S1E-H).


(H)igher RBD-specific B cells compared to the paired blood samples (Fig. 3D), suggesting that vaccination does not induce tissue-residing memory B cell responses as effectively as natural infection. Further, BAL from COVID-19 convalescents had higher cytokine-producing CD8+ and CD4 T+ cells than those of blood (Fig. 3E, F,…Within the total CD8+ or CD4+ T cell compartments, the levels of most memory T cell subsets in the blood and/or BAL were quite similar between unvaccinated or vaccinated individuals, except the blood central memory T cell population (Fig. S4). Thus, unlike SARS-CoV-2 natural infection, mRNA vaccination did not appear to induce significant SARS-CoV-2 specific B and T cell memory in the respiratory mucosa in contrast to that in the blood in our cohorts. “ see: Frontiers | Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2 (frontiersin.org)

More Recent supporting evidence.

“On October 24, 2022, David Ho and colleagues released the results of a study examining levels of neutralizing antibodies against BA.4 and BA.5 after receipt of a monovalent or bivalent booster dose. They found “no significant difference in neutralization of any SARS-CoV-2 variant,” https://www.nejm.org/doi/full/10.1056/NEJMp2215780?query=recirc_mostViewed_railB_article including BA.4 and BA.5

“Why did the strategy for significantly increasing BA.4 and BA.5 neutralizing antibodies using a bivalent vaccine fail? The most likely explanation is imprinting. The immune systems of people immunized with the bivalent vaccine, all of whom had previously been vaccinated, were primed to respond to the ancestral strain of SARS-CoV-2. They therefore probably responded to epitopes shared by BA.4 and BA.5 and the ancestral strain, rather than to new epitopes on BA.4 and BA.5.” Says Paul A, Offit M.D and member of the FDA’s Vaccines and Related Biological Products Advisory Committee

The Bottom Line” Build your Immune System Naturally through Proper Exercise like Tai Chi and Qigong with a balanced diet and proper Hygiene.

Qigong for the Prevention, Treatment, and Rehabilitation of COVID-19 Infection in Older Adults

Conclusion: The available biological and psychological evidence suggest Qigong may be potentially useful for the prevention, treatment, and rehabilitation of respiratory infections, including COVID-19. The elderly, in particular, could benefit from Qigong during the ongoing pandemic, for it is easy to practice.